Busted! Exercise Study Finds Energy Production System is Broken in CFS

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    • Busted! Exercise Study Finds Energy Production System is Broken in CFS

      [h=3]Busted! Exercise Study Finds Energy Production System is Broken in Chronic Fatigue Syndrome[/h]


      Car Wreck on ME/CFS Patients ‘Oxygen Highway’… Clean vs Dirty Energy Production


      Keep your eyes on the oxygen molecule. Your body thrives on it. It’s at the heart of your aerobic energy production system. When it’s working correctly you’re filled with clean, abundant energy. When its not you’re in trouble.

      You have a clean and efficient energy producing system and a ‘dirty and inefficient energy producing system. Guess which one is broken in ME/CFS?

      Multiple systems explode into action in order to get that oxygen to your muscles when you exercise. You breath more deeply and your heart pumps harder and faster to transport it just as quickly as it can to your cells. That heart/lung/muscle connection is the oxygen highway.

      You have a second (mostly backup) energy production system but it’s a dirty, inefficient and even painful system to use. Called anaerobic glycolysis it mostly kicks in only after your aerobic (oxygen-using) energy production system has pooped out. If you exercise long and hard enough (or if you have ME/CFS - not very long and not very hard) the pain and fatigue you experience when you switch to anaerobic system is unmistakeable.

      As soon as you make that switch – at what researchers call your ‘anaerobic threshold’ – toxins are going to start building up in your muscles and you’re probably not going to be exercising that much longer. ( ‘Aerobic threshold’ might be a better name for a switch point that represents the end of clean (ie aerobic) energy production, and a dependence on anaerobic metabolism.)

      At that point things get complicated quickly. With anaerobic glycolysis comes lactic acid, and with lactic acid comes lactate, and with lactate comes CO2, and with CO2 comes a big problem. CO2 displaces oxygen – the life blood of our system – so it’s got to be removed fast, and so into the blood and out the lungs it goes. As the CO2 levels in your blood rise your breathing rate speeds up automatically just to get it out of your system.

      Read more: Busted! Exercise Study Finds Energy Production System is Broken in Chronic Fatigue Syndrome
    • Sherrie, this answered several questions for me. Thank you!

      I liked the bullet list at the end:

      To reiterate the CPET maximal exercise test-retest smashes the deconditioning argument to bits

      provides a metabolic basis for the exertion problems in ME/CFS

      relies on commonly used equipment that has been used to validate dysfunction in many disorders (unlike much cutting-edge research in ME/CFS).

      provides the best evidence for disability possible appears to identify a core issue that many people with ME/CFS,

      young and old, highly disabled and more functional share can differentiate between people with ME/CFS who have metabolic issues and people who are equally low functioning but don’t have them.


      Just as obesity is due to "worn-out" or damaged mitochondria, it seems the ME/CFS is, too. Trying to heal the mitochondria is why I keep to my food plan: what I eat, how much, and when.

      Thanks again, for posting this. I find it most useful information.
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