Effect of a Low-Carbohydrate Diet on Appetite, Blood Glucose Levels,

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    • Effect of a Low-Carbohydrate Diet on Appetite, Blood Glucose Levels,

      Heres one I came across, this one is a strict supervised study for 3 weeks in a hospital with 10 obese people with type 2 diabetes. 1 week normal diet and then 2 weeks on Atkins induction.

      The PDF is available in full for free as it is over 6 months old.


      Effect of a Low-Carbohydrate Diet on Appetite, Blood Glucose Levels, and Insulin Resistance in Obese Patients with Type 2 Diabetes
      Guenther Boden, MD; Karin Sargrad, MS, RD, CDE; Carol Homko, PhD, RN, CDE; Maria Mozzoli, BS; and T. Peter Stein, PhD


      ABSTRACT

      Background: It is not known how a low-carbohydrate, highprotein,
      high-fat diet causes weight loss or how it affects blood glucose levels in patients with type 2 diabetes.

      Objective:
      To determine effects of a strict low-carbohydrate diet
      on body weight, body water, energy intake and expenditure, glycemic
      control, insulin sensitivity, and lipid levels in obese patients with type 2 diabetes.

      Design: Inpatient comparison of 2 diets.

      Setting:
      General clinical research center of a university hospital.

      Patients: 10 obese patients with type 2 diabetes.

      Intervention: Usual diets for 7 days followed by a low-carbohydrate
      diet for 14 days.

      Measurements: Body weight, water, and composition; energy
      intake and expenditure; diet satisfaction; hemoglobin A1c; insulin
      sensitivity; 24-hour urinary ketone excretion; and plasma profiles of glucose, insulin, leptin, and ghrelin.

      Results: On the low-carbohydrate diet, mean energy intake decreased
      from 3111 kcal/d to 2164 kcal/d. The mean energy deficit of 1027 kcal/d (median, 737 kcal/d) completely accounted for the weight loss of 1.65 kg in 14 days (median, 1.34 kg in 14 days).
      Mean 24-hour plasma profiles of glucose levels normalized, mean
      hemoglobin A1c decreased from 7.3% to 6.8%, and insulin sensitivity
      improved by approximately 75%. Mean plasma triglyceride and cholesterol levels decreased (change, 35% and 10%, respectively).

      Limitations: The study was limited by the short duration, small
      number of participants, and lack of a strict control group.

      Conclusion: In a small group of obese patients with type 2
      diabetes, a low-carbohydrate diet followed for 2 weeks resulted in
      spontaneous reduction in energy intake to a level appropriate to
      their height; weight loss that was completely accounted for by
      reduced caloric intake; much improved 24-hour blood glucose
      profiles, insulin sensitivity, and hemoglobin A1c; and decreased
      plasma triglyceride and cholesterol levels. The long-term effects of
      this diet, however, remain uncertain.

      Full PDF: Ann Intern Med. 2005;142:403-411.

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      Let me know if you think of anything else handy from the site to put here.